Protein Modification Reagents
eMolecules 16-(Amine-PEG4-ethylcarbamoyl)pentadecanoic-t-butyl ester | Broadpharm |560.817 | C30H60N2O7 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCN | 100mg | 795361477
16-(Amine-PEG4-ethylcarbamoyl)pentadecanoic-t-butyl ester | Broadpharm |560.817 | C30H60N2O7 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCN | 100mg | 795361477
Medchemexpress LLC PEG5-Tos | 155130-15-7 | 96.9% | 392.46 | 1 G
PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
Medchemexpress LLC Amino-PEG4-C2-SH hydrochloride | 95.0% | 289.82 g/mol | C10H24ClNO4S | 5 MG
Amino-PEG4-C2-SH hydrochloride is a PEG-based PROTAC linker supplied as the hydrochloride salt for research use. The molecule features a PEG4 spacer with a terminal amino group and a terminal thiol, enabling orthogonal conjugation strategies in bifunctional molecule synthesis. It is provided with characterized purity and molecular weight suitable for medicinal chemistry and linker development applications.
- Hydrochloride salt for improved handling and stability.
- Terminal amino and thiol groups for orthogonal conjugation.
- PEG4 spacer provides flexibility and aqueous solubility.
- Characterized purity for research-grade synthesis.
- Intended for use in PROTAC and linker chemistry.
Medchemexpress LLC PEG5-(CH2CO2H)2 | 77855-75-5 | MFCD29079379 | 99.3% | 310.30 | C12H22O9 | 1G
HOOCCH2O-PEG4-CH2COOH is a symmetric PEG-based dicarboxylic acid linker used as a flexible, hydrophilic spacer for the construction of bifunctional degraders and other conjugates. It provides two carboxylic acid termini for standard coupling chemistries, and its PEG4 backbone imparts solubility and conformational flexibility suited for PROTAC and homo-PROTAC synthesis.
- Symmetric PEG4 dicarboxylic acid linker.
- Provides carboxylic acid termini for straightforward coupling reactions.
- PEG backbone increases solubility and flexibility.
- Designed for use in PROTAC and homo-PROTAC synthesis.
- High purity suitable for research applications.
- Typically supplied in small pack sizes for lab-scale synthesis.
eMolecules m-PEG8-BBTA | Broadpharm |742.840 | C36H46N4O11S | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)Nc1ccc2nc(oc2c1)-c1ccc(s1)-c1nc2ccc(N)cc2o1 | 1mg | 518001028
m-PEG8-BBTA | Broadpharm |742.840 | C36H46N4O11S | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)Nc1ccc2nc(oc2c1)-c1ccc(s1)-c1nc2ccc(N)cc2o1 | 1mg | 518001028
Cayman Chemical XnthIn amIn congenr 10mg
A non-selective adenosine receptor antagonist (Kbs = 83, 25, and 15 nM for rat PC 12 cells, human platelets, and rat fat cells, respectively); reduces NECA-stimulated adenylate cyclase activity in human platelets (EC50s = 1 and 0.31 μM in the presence and absence of XAC, respectively); reverses R-PIA-induced inhibition of isoproterenol-stimulated adenylate cyclase activity in rat fat cell membranes (IC50s = 146 and 26 nM in the presence and absence of XAC, respectively); reverses 2-CADO-, R-PIA-, and NECA-induced reductions in heart rate and blood pressure in rats (0.1-1.0 mg/kg); induces convulsions in mice (39.8 mg/kg)
eMolecules 1286281-32-0 | Amino-PEG6-t-butyl ester | Broadpharm | MFCD13184944 | 409.520 | C19H39NO8 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCN | 1g | 112541647
Amino-PEG6-t-butyl ester | Broadpharm | 1286281-32-0 | MFCD13184944 | 409.520 | C19H39NO8 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCN | 1g | 112541647
Medchemexpress LLC Boc-N-Amido-PEG4-propargyl | 1219810-90-8 | 99.7% | C16H29NO6 | 100 MG
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs themselves contain two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase, and the other for the target protein, enabling PROTACs to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Dope-peg-mal | 98.2% | 2000 Da | 5 MG
DOPE-PEG-Mal (MW 2000) is a maleimide-functionalized dioleoyl phosphoethanolamine-polyethylene glycol conjugate formulated for liposome and nanoparticle preparation and for covalent attachment to thiol-containing ligands. The maleimide group enables rapid, selective thiol coupling under mild conditions to yield stable thioether linkages; the PEG moiety (average MW ~2000 Da) provides steric stabilization in formulations.
- Maleimide-functionalized lipid for thiol conjugation.
- Selective thiol reactivity at pH 6.5-7.5 forming stable thioether bonds.
- Suitable for liposome and nanoparticle formulation.
- Average PEG molecular weight ~2000 Da for steric stabilization.
- High reported purity (≈98.2%).
- Available in small research pack sizes for formulation work.
eMolecules 1315355-92-0 | Mal-amido-PEG5-NHS | Broadpharm | MFCD20230002 | 557.553 | C24H35N3O12 | 95.000 | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 100mg | 795361687
Mal-amido-PEG5-NHS | Broadpharm | 1315355-92-0 | MFCD20230002 | 557.553 | C24H35N3O12 | 95.000 | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 100mg | 795361687
CCOCCOCCN1C(=O)C=CC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1 | 50mg | 368397818](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203338.JPG-250.jpg)
eMolecules 2055041-38-6 | Mal-PEG2-Val-Cit-PAB-OH | Broadpharm | MFCD29918233 | 618.688 | C29H42N6O9 | 0.000 | CC(C)[C@H](NC(=O)CCOCCOCCN1C(=O)C=CC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1 | 50mg | 368397818
Mal-PEG2-Val-Cit-PAB-OH | Broadpharm | 2055041-38-6 | MFCD29918233 | 618.688 | C29H42N6O9 | 0.000 | CC(C)[C@H](NC(=O)CCOCCOCCN1C(=O)C=CC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1 | 50mg | 368397818
Cayman Chemical DL-DIthIothreItol 1g
A reducing agent; has been used to stabilize thiols in a reduced state in various applications, including protein purification and enzymatic assays
Medchemexpress LLC Carboxyethyl-γ-aminobutyric acid | 4386-03-2 | MFCD00057954 | 175.18 g/mol | C7H13NO4 | 10 MG
Carboxyethyl-γ-aminobutyric acid is a small-molecule biochemical reagent supplied as a powder for laboratory research. Identified by CAS 4386-03-2, it has formula C7H13NO4 and molecular weight 175.18 g/mol. Store and handle according to the safety data sheet and product documentation.